Human umbilical cord mesenchymal stem cell treatment alleviates symptoms in an atopic dermatitis-like mouse model.

ABSTRACT:

Background

Atopic dermatitis (AD) is one of the most common immune and inflammatory skin disorders, leading to insufferable itching and skin abnormalities that seriously affect life quality of patients. There are still huge unmet needs for long-term and effective disease control, despite currently available therapies. Evidenced by some preclinical and clinical studies of AD treatment with stem cells, stem cell treatment could significantly and effectively ameliorate AD symptoms.

Objectives

To elucidate underlying mechanisms of how stem cells therapy alleviates AD-like symptoms.

Methods

An AD-like mouse model was constructed and treated with mesenchymal stem cells (MSCs) subcutaneously or subcutaneously combined with intravenously. The differentially expressed genes we

SUBMITTER: Hua C 

PROVIDER: S-EPMC10227992 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature