ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.

ABSTRACT:

Background

The human genome contains nearly 20.000 protein-coding genes, but there are still more than 6,000 proteins poorly characterized. Among them, ZNF330/NOA36 stand out because it is a highly evolutionarily conserved nucleolar zinc-finger protein found in the genome of ancient animal phyla like sponges or cnidarians, up to humans. Firstly described as a human autoantigen, NOA36 is expressed in all tissues and human cell lines, and it has been related to apoptosis in human cells as well as in muscle morphogenesis and hematopoiesis in Drosophila. Nevertheless, further research is required to better understand the roles of this highly conserved protein.

Results

Here, we have investigated possible interactors of human ZNF330/NOA36 through affinity-purification mass spectro

SUBMITTER: Sanchez-Brinas A 

PROVIDER: S-EPMC10228019 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature