Resistance to mutant KRAS^V12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line.

ABSTRACT: Mutant KRAS, the most frequently occurring (∼30%) driver oncogene in lung adenocarcinoma, induces normal epithelial cells to undergo senescence. This phenomenon, called "oncogene-induced senescence (OIS)", prevents mutant KRAS-induced malignant transformation. We have previously reported that mutant KRAS^V12 induces OIS in a subset of normal human bronchial epithelial cell line immortalized with hTERT and Cdk4. Understanding the mechanism and efficacy of this important cancer prevention mechanism is a key knowledge gap. Therefore, this study investigates mutant KRAS^V12-induced OIS in upregulated telomerase combined with the p16/RB pathway inactivation in normal bronchial epithelial cells. The normal (non-transformed and non-tumorigenic) human bronchial epithelial cell

SUBMITTER: Muraki N 

PROVIDER: S-EPMC10228173 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature