Age as a moderating factor of treatment resistance in depression.

ABSTRACT:

Background

Treatment-resistant depression (TRD) is an important clinical challenge and may present differently between age groups.

Methods

A total of 893 depressed patients recruited within the framework of the European research consortium "Group for the Studies of Resistant Depression" were assessed by generalized linear models regarding age effects (both as numerical and factorial predictors) on treatment outcome, number of lifetime depressive episodes, hospitalization time, and duration of the current episode. Effects of age as numerical predictor on the severity of common depressive symptoms, measured with Montgomery-Åsberg Depression Rating Scale (MADRS) for two-time points, were assessed by linear mixed models, respectively, for patients showing TRD and treatment respo

SUBMITTER: Kautzky A 

PROVIDER: S-EPMC10228354 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature