Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study.

ABSTRACT:

Objective

Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification and developing better-tailored therapeutic targets.

Methods

TRS-related proteome-wide association studies (PWAS) were conducted on genome-wide association studies (GWAS) from CLOZUK and the Psychiatric Genomics Consortium (PGC), which provided TRS individuals (n = 10,501) and non-TRS individuals (n = 20,325), respectively. The reference datasets for the human brain proteome were obtained from ROS/MAP and Banner, with 8,356 and 11,518 proteins collected, respectively. We then performed colocalization analysis and f

SUBMITTER: Wei W 

PROVIDER: S-EPMC10228356 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature