CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants.

ABSTRACT: The expression of viral antigens in chronic hepatitis B virus (HBV) infection drives continuous liver inflammation, one of the main risk factors to develop liver cancer. HBV developed immune-suppressive functions to escape from the host immune system, but their link to liver tumor development is not well understood. Here, we analyzed if and how HBV surface antigen (HBs) expression in combined hepatocellular-cholangiocarcinoma (cHCC/iCCA) cells influences their antigenicity for CD8 T cells. We randomly isolated liver tumor tissues from AlfpCre⁺-Trp53^fl/fl/Alb-HBs⁺ tg mice and established primary carcinoma cell lines (pCCL) that showed a bilineal (CK7⁺/HNF4α⁺) cHCC/iCCA phenotype. These pCCL uniformly expressed HBs (HBs^hi), an

SUBMITTER: Qiu N 

PROVIDER: S-EPMC10228399 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature