Genetic risk score prediction of leg fat and insulin sensitivity differs by race/ethnicity in early pubertal children.

ABSTRACT:

Background

In the United States, the underlying reasons for racial/ethnic disparities in type 2 diabetes risk remain unclear. However, differences in genetic risk for insulin resistance and peripheral adipose tissue distribution may be contributing factors.

Objective

To investigate racial/ethnic differences in associations of genetic risk for insulin resistance with leg fat and insulin sensitivity in a cohort of American children.

Methods

Participants were healthy European-American (n = 83), African-American (n = 79) and Hispanic-American (n = 74) children aged 7-12 years. Genetic risk scores were derived from published variants associated with insulin resistance phenotypes in European adults. Body composition was assessed using dual-energy X-ray absorptiometry. Insul

SUBMITTER: Fowler LA 

PROVIDER: S-EPMC10228538 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature