Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke.

ABSTRACT:

Aims

Atrial fibrillation (AF) is one of the major causes of ischaemic stroke. In addition to clinical risk evaluated by the CHA2DS2-VASC score, the impact of genetic factors on the risk of AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with thromboembolic stroke risk in our AF patients by genome-wide approach. Among them, the gasdermin D (GSDMD) gene was related to inflammation. We aimed to test whether GSDMD deletion was associated with AF-related stroke.

Methods and results

A total of 400 patients with documented non-familial AF were selected, of which 100 patients were diagnosed with ischaemic stroke. The baseline characteristics of age, sex, valvular heart disease, coronary art

SUBMITTER: Huang PS 

PROVIDER: S-EPMC10228625 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature