Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus.

ABSTRACT: Plastic pollution breaks a planetary boundary threatening wildlife and humans through its physical and chemical effects. Of the latter, the release of endocrine disrupting chemicals (EDCs) has consequences on the prevalence of human diseases related to the endocrine system. Bisphenols (BPs) and phthalates are two groups of EDCs commonly found in plastics that migrate into the environment and make low-dose human exposure ubiquitous. Here we review epidemiological, animal, and cellular studies linking exposure to BPs and phthalates to altered glucose regulation, with emphasis on the role of pancreatic β-cells. Epidemiological studies indicate that exposure to BPs and phthalates is associated with diabetes mellitus. Studies in animal models indicate that treatment with doses within the range

SUBMITTER: Martinez-Pinna J 

PROVIDER: S-EPMC10228669 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature