Identification of CDRH3 loops in the B cell receptor repertoire that can be engaged by candidate immunogens.

ABSTRACT: A major goal for the development of vaccines against rapidly mutating viruses, such as influenza or HIV, is to elicit antibodies with broad neutralization capacity. However, B cell precursors capable of maturing into broadly neutralizing antibodies (bnAbs) can be rare in the immune repertoire. Due to the stochastic nature of B cell receptor (BCR) rearrangement, a limited number of third heavy chain complementary determining region (CDRH3) sequences are identical between different individuals. Thus, in order to successfully engage broadly neutralizing antibody precursors that rely on their CDRH3 loop for antigen recognition, immunogens must be able to tolerate sequence diversity in the B cell receptor repertoire across an entire vaccinated population. Here, we present a combined experimenta

SUBMITTER: Swanson O 

PROVIDER: S-EPMC10228794 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature