Functional inference of long non-coding RNAs through exploration of highly conserved regions.

ABSTRACT: Background: Long non-coding RNAs (lncRNAs), which are generally less functionally characterized or less annotated, evolve more rapidly than mRNAs and substantially possess fewer sequence conservation patterns than protein-coding genes across divergent species. People assume that the functional inference could be conducted on the evolutionarily conserved long non-coding RNAs as they are most likely to be functional. In the past decades, substantial progress has been made in discussions on the evolutionary conservation of non-coding genomic regions from multiple perspectives. However, understanding their conservation and the functions associated with sequence conservation in relation to further corresponding phenotypic variability or disorders still remains incomplete. Results:

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10229068 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature