Ontology highlight
ABSTRACT:
SUBMITTER: Vuckovic Z
PROVIDER: S-EPMC10229135 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Vuckovic Ziva Z Wang Jinan J Pham Vi V Mobbs Jesse I JI Belousoff Matthew J MJ Bhattarai Apurba A Burger Wessel A C WAC Thompson Geoff G Yeasmin Mahmuda M Nawaratne Vindhya V Leach Katie K van der Westhuizen Emma T ET Khajehali Elham E Liang Yi-Lynn YL Glukhova Alisa A Wootten Denise D Lindsley Craig W CW Tobin Andrew A Sexton Patrick P Danev Radostin R Valant Celine C Miao Yinglong Y Christopoulos Arthur A Thal David M DM
eLife 20230530
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR allosteric modulators remains limited. The M<sub>4</sub> muscarinic acetylcholine receptor (M<sub>4</sub> mAChR) is a validated and clinically relevant allosteric drug target for several major psychiatric and cognitive disorders. In this study, we ri ...[more]