Failing categorization of severe COVID-19 ARDS into ventilatory subphenotypes studied via the clinical-histopathologic relationship.

ABSTRACT:

Background

Categorization of severe COVID-19 related acute respiratory distress syndrome (CARDS) into subphenotypes does not consider the trajectories of respiratory mechanoelastic features and histopathologic patterns. This study aimed to assess the correlation between mechanoelastic ventilatory features and lung histopathologic findings in critically ill patients who died because of CARDS.

Methods

Mechanically ventilated patients with severe CARDS who had daily ventilatory data were considered. The histopathologic assessment was performed through full autopsy of deceased patients. Patients were categorized into two groups according to the median worst respiratory system compliance during ICU stay (Crs_ICU).

Results

Eighty-seven patients admitted to ICU had

SUBMITTER: Colombo R 

PROVIDER: S-EPMC10229208 | biostudies-literature | 2023 Aug-Sep

REPOSITORIES: biostudies-literature