Mechanistic investigation of direct photodegradation of chloroquine phosphate under simulated sunlight.

ABSTRACT: Chloroquine phosphate (CQ) is an antiviral drug for Coronavirus Disease 2019 and an old drug for treatment of malaria, which has been detected in natural waters. Despite its prevalence, the environmental fate of CQ remains unclear. In this study, the direct photodegradation of CQ under simulated sunlight was investigated. The effect of various parameters such as pH, initial concentration and environmental matrix were examined. The photodegradation quantum yield of CQ (4.5 × 10^-5-0.025) increased with the increasing pH value in the range of 6.0-10.0. The electron spin resonance (ESR) spectrometry and quenching experiments verified that the direct photodegradation of CQ was primarily associated with excited triplet states of CQ (³CQ*). The common ions had negligible eff

SUBMITTER: Xiang W 

PROVIDER: S-EPMC10229258 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature