Fast correction of B₀ field inhomogeneity for pH-specific magnetization transfer and relaxation normalized amide proton transfer imaging of acute ischemic stroke without Z-spectrum.

ABSTRACT:

Purpose

The magnetization transfer and relaxation normalized amide proton transfer (MRAPT) analysis is promising to provide a highly pH-specific mapping of tissue acidosis, complementing commonly used CEST asymmetry analysis. We aimed to develop a fast B₀ inhomogeneity correction algorithm for acute stroke magnetization transfer and relaxation normalized amide proton transfer imaging without Z-spectral interpolation.

Methods

The proposed fast field inhomogeneity correction describes B₀ artifacts with linear regression. We compared the new algorithm with the routine interpolation correction approach in CEST imaging of a dual-pH phantom. The fast B₀ correction was further evaluated in amide proton transfer imaging of normal and acute stroke rat

SUBMITTER: Sun PZ 

PROVIDER: S-EPMC10229259 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature