Total cortical interstitial inflammation predicts chronic kidney disease progression in patients with lupus nephritis.

ABSTRACT:

Background

End-stage kidney disease (ESKD) from lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Kidney biopsy is the gold standard for diagnosis and prognostication of LN. While interstitial fibrosis and tubular atrophy (IFTA) predict progression to ESKD, the National Institutes of Health (NIH) classification of interstitial inflammation in unscarred cortical parenchyma is not predictive of chronic kidney disease (CKD) progression. The objective of this study was to determine whether total cortical interstitial inflammation that accounts for inflammation in the entire cortical parenchyma could predict CKD progression in patients with LN. Early identification of at-risk patients may improve outcomes.

Methods

SUBMITTER: Duong MD 

PROVIDER: S-EPMC10229284 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature