Mineral, trace element, and toxic metal concentration in hair from dogs with idiopathic epilepsy compared to healthy controls.

ABSTRACT:

Background

Altered trace element status is associated with epilepsy in humans and dogs with idiopathic epilepsy (IE).

Objectives

Compare hair element concentrations in epileptic and healthy dogs.

Animals

Sixty-three dogs with IE (53 treated, 10 untreated) and 42 controls.

Methods

Case-control study using ICP-MS to determine hair calcium, magnesium, phosphorus, sodium, potassium, iron, copper, manganese, zinc, selenium, chromium, lead, mercury, cadmium, arsenic, aluminum, and nickel concentration. Groups were compared using nonparametric tests. Results were controlled for diet, sex, age, and hair color using generalized linear mixed models.

Results

Compared to healthy controls, dogs with IE had lower hair phosphorus (mean ± SD; IE: 286.19 ± 69.62 μg/g, he

SUBMITTER: Rosendahl S 

PROVIDER: S-EPMC10229330 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature