Serum proteome of dogs with chronic enteropathy.

ABSTRACT:

Background

Chronic enteropathy (CE) is common in dogs and can occur with multiple etiologies including food-responsive enteropathy (FRE) and idiopathic inflammatory bowel disease (IBD).

Hypothesis/objective

To study the protein profile and pathway differences among dogs with FRE, IBD, and healthy controls using serum proteome analysis.

Animals

Nine CE dogs with signs of gastrointestinal disease and histologically confirmed chronic inflammatory enteropathy and 16 healthy controls.

Methods

A cross-sectional study with cases recruited from 2 veterinary hospitals between May 2019 and November 2020 was performed. Serum samples were analyzed using mass spectrometry-based proteomic techniques.

Results

Proteomic profiles showed marked variation in relative prote

SUBMITTER: Yu J 

PROVIDER: S-EPMC10229361 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature