Serum nerve growth factor in horses with osteoarthritis-associated lameness.

ABSTRACT:

Background

Nerve growth factor (NGF) is a neurotrophin that is increased in osteoarthritic joints of horses. In humans, NGF has been associated with pain, and both synovial and serum NGF concentrations are increased in osteoarthritic patients. Studies in humans also have shown that serum NGF concentration can increase with stress. Serum NGF concentration should be evaluated in horses with osteoarthritis-associated lameness.

Objectives

Quantify and compare serum NGF concentration in horses with osteoarthritis-associated lameness and sound horses. Additionally, the impact of short-term stress on serum NGF concentration was investigated.

Animals

Lame horses with radiographic evidence of osteoarthritis (n = 20), lame horses without radiographic changes in the affected joi

SUBMITTER: Kendall A 

PROVIDER: S-EPMC10229367 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature