Evaluation of an HMGA2 variant contribution to height and basal insulin concentrations in ponies.

ABSTRACT:

Background

The HMGA2:c.83G>A variant was identified in Welsh ponies having pleiotropic effects on height and insulin concentration.

Objective

Determine whether the HMGA2:c.83G>A variant is associated with decreased height and higher basal insulin concentrations across pony breeds.

Animals

Two hundred thirty-six ponies across 6 breeds.

Methods

Cross-sectional study. Ponies were genotyped for the HMGA2:c.83G>A variant and phenotyped for height and basal insulin concentrations. Stepwise regression was performed for model analysis using a linear regression model for height and mixed linear model for insulin with farm as a random effect. Coefficient of determination, pairwise comparison of the estimated marginal means and partial correlation coefficients (parcor) we

SUBMITTER: Clark BL 

PROVIDER: S-EPMC10229368 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature