The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease.

ABSTRACT:

Background

The behavior of the comprehensive circulating renin-angiotensin system (RAS) in dogs with myxomatous mitral valve disease (MMVD) before to the onset of congestive heart failure remains largely unexplored.

Hypothesis/objectives

The classical and alternative RAS activity and aldosterone concentrations will be significantly higher in dogs with American College of Veterinary Internal Medicine (ACVIM) stage B2 MMVD compared to normal dogs and dogs with ACVIM stage B1 MMVD.

Animals

One-hundred seventeen client-owned dogs (normal = 60; B1 = 31; B2 = 26).

Methods

Prospective observational study. Angiotensin peptides (AP) and aldosterone concentrations were measured using liquid chromatography and mass spectrometry. Angiotensin converting enzymes 1 and 2 (ACE

SUBMITTER: Hammond HH 

PROVIDER: S-EPMC10229370 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature