Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers.

ABSTRACT:

Purpose

A population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and different dosing regimens were evaluated in terms of the probability of target attainment for Escherichia coli using both plasma and urinary pharmacokinetic/pharmacodynamic targets.

Methods

Eight healthy men received fosfomycin as both intermittent 8 g q8h and continuous infusion 1 g/h with a loading dose of 8 g in a crossover study design. Dense sampling was conducted during both regimens. Population pharmacokinetic modelling was performed using NONMEM. Monte Carlo simulations were conducted to evaluate the Probability of Target Attainment (PTA) of different dosing regimens using bactericidal (AUC_24h/MIC of 83 and 75%T_>MIC)

SUBMITTER: Edwina AE 

PROVIDER: S-EPMC10229474 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature