Cardiovascular characterisation of a novel mouse model that combines hypertension and diabetes co-morbidities.

ABSTRACT: Epidemiologic data suggest that the prevalence of hypertension in patients with diabetes mellitus is ∼1.5-2.0 times greater than in matched non-diabetic patients. This co-existent disease burden exacerbates cardiac and vascular injury, leading to structural and functional changes to the myocardium, impaired cardiac function and heart failure. Oxidative stress and persistent low-grade inflammation underlie both conditions, and are identified as major contributors to pathological cardiac remodelling. There is an urgent need for effective therapies that specifically target oxidative stress and inflammation to protect against cardiac remodelling. Animal models are a valuable tool for testing emerging therapeutics, however, there is a notable lack of appropriate animal models of co-morbid diabe

SUBMITTER: Sharma A 

PROVIDER: S-EPMC10229541 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature