B cell-specific knockout of AID protects against atherosclerosis.

ABSTRACT: Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would thus be expected to foster atherosclerosis. Yet, AID also plays a major role in the establishment of B cell tolerance. We sought to define whether AID affects atherosclerotic plaque formation. We generated Ldlr^-/- chimeras transplanted with bone marrow from Aicda^-/- or wild-type (WT) mice, fed a HFD for 14 weeks. Decreased B cell maturation in Ldlr^-/-Aicda^-/- mice was demonstrated by 50% reduction in splenic and aortic BAFFR expression, a key signaling component of B2 cell maturation. This was associated with

SUBMITTER: Ebrahimian T 

PROVIDER: S-EPMC10229602 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature