The potential impact of coagulation factor XIII in trauma-induced coagulopathy - a retrospective case series analysis.

ABSTRACT:

Background

The role of factor XIII (FXIII) in trauma-induced coagulopathy (TIC) is not fully understood.

Methods

We evaluated FXIII supplementation in severely injured patients with persistent bleeding. This was a retrospective case series analysis.

Results

Twenty-four patients received FXIII concentrate within 24 h of admission for bleeding that continued after transfusion of > 6 U red blood cells (RBCs); control patients (n = 27) did not receive FXIII concentrate. Both study groups were similar regarding injury severity score and global coagulation tests, but FXIII activity levels were significantly higher and lactate levels significantly lower in the control group, respectively. The differences in FXIII activity between the groups could be attributed to a more seve

SUBMITTER: Wilhelmi M 

PROVIDER: S-EPMC10229685 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature