Chronic corticosterone exposure disrupts hepatic and intestinal bile acid metabolism in chicken.

ABSTRACT:

Objective

Chronic stress leads to a high circulating level of glucocorticoids, which disrupts lipid metabolism and causes non-alcoholic fatty liver disease in mice and humans. Meanwhile, bile acid (BA), a class of metabolites initially synthesized in the liver and further metabolized by gut microbiota, plays a vital role in lipid metabolism. This study aimed to investigate the effects of glucocorticoids on BA metabolism and gut microbiota in chickens.

Methods

In this study, 35-day-old chickens were injected with 4 mg/kg/day corticosterone (Cort) for 14 days to simulate chronic stress.

Results

Cort treatment significantly increased the triglyceride contents in the plasma and the liver. HE and oil-red staining showed that Cort treatment induced fatty liver in chickens.

SUBMITTER: Wu L 

PROVIDER: S-EPMC10229839 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature