Soluble monomeric human programmed cell death-ligand 1 inhibits the functions of activated T cells.

ABSTRACT:

Introduction

The presence of soluble human programmed cell death-ligand 1 (shPD-L1) in the blood of patients with cancer has been reported to be negatively correlated with disease prognosis. However, little information exists about the mechanisms underlying high levels of shPD-L1 for promoting disease progression.

Methods

In this study, we first analyzed the correlations between shPD-L1 and apoptosis of T cells in patients with cancer, then tested the effect of shPD-L1 on T-cell functions and the production of regulatory T cells.

Results

We found that the apoptosis of human peripheral PD-1+CD4+ T cells was significantly elevated in patients with cancer compared with healthy donors and was positively correlated with circulating PD-L1 levels in patients with cancer. In

SUBMITTER: Liang Z 

PROVIDER: S-EPMC10229872 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature