Language dysfunction correlates with cognitive impairments in older adults without dementia mediated by amyloid pathology.

ABSTRACT:

Background

Previous studies have explored the application of non-invasive biomarkers of language dysfunction for the early detection of Alzheimer's disease (AD). However, language dysfunction over time may be quite heterogeneous within different diagnostic groups.

Method

Patient demographics and clinical data were retrieved from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database for the participants without dementia who had measures of cerebrospinal fluid (CSF) biomarkers and language dysfunction. We analyzed the effect of longitudinal neuropathological and clinical correlates in the pathological process of semantic fluency and confrontation naming. The mediation effects of AD biomarkers were also explored by the mediation analysis.

Result

There were 272

SUBMITTER: Xiang C 

PROVIDER: S-EPMC10230042 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature