Clinical and immune-related factors associated with exacerbation in adults with well-controlled generalized myasthenia gravis.

ABSTRACT:

Objectives

To describe the clinical predictors and immune-related factors for exacerbation in adults with well-controlled generalized myasthenia gravis (GMG).

Methods

We conducted a retrospective analysis of 585 adults with well-controlled GMG from our institution to explore the risk factors for exacerbation. Furthermore, propensity score matching (PSM) was used to compare the proportions of lymphocyte subsets, and the levels of immunoglobulin, complement, and anti-acetylcholine receptor antibody (AChR-ab) in the peripheral blood of 111 patients with exacerbations and 72 patients without exacerbations.

Results

A total of 404 patients (69.1%) experienced at least one exacerbation, and the median (interquartile range) time to the first exacerbation was 1.5 years (0.8-3.

SUBMITTER: Bi Z 

PROVIDER: S-EPMC10230065 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature