Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?

ABSTRACT: For those born with cystic fibrosis (CF), hyper-concentrated mucus with a dysfunctional structure significantly impacts CF airways, providing a perfect environment for bacterial colonization and subsequent chronic infection. Early treatment with antibiotics limits the prevalence of bacterial pathogens but permanently alters the CF airway microenvironment, resulting in antibiotic resistance and other long-term consequences. With little investment into new traditional antibiotics, safe and effective alternative therapeutic options are urgently needed. One gathering significant traction is bacteriophage (phage) therapy. However, little is known about which phages are effective for respiratory infections, the dynamics involved between phage(s) and the host airway, and associated by-products, i

SUBMITTER: Ling KM 

PROVIDER: S-EPMC10230084 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature