Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review.

ABSTRACT:

Objectives

Gut dysbiosis is believed to be one of the several mechanisms that are involved in the pathogenesis of gout. This systematic review aimed to summarize the role of gut dysbiosis in gout disease and uncover the underlying mechanisms.

Methods

A comprehensive search was conducted on PubMed, Web of Science, and Scopus databases up to October 2021. Animal studies and human observational studies, including case-control, cross-sectional, and cohort studies assessing the association between gut microbiota composition and gout were included. The quality of included studies has been evaluated using the Newcastle-Ottawa Quality Assessment scale (NOS) and the SYRCLE's risk of bias tool.

Results

Initially, we found 274 studies among which 15 studies were included in this

SUBMITTER: Shirvani-Rad S 

PROVIDER: S-EPMC10230090 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature