HRG inhibits liver cancer lung metastasis by suppressing neutrophil extracellular trap formation.

ABSTRACT:

Background

Distant metastasis is a sign of poor prognosis for cancer patients. Extrahepatic liver cancer metastases commonly spread to the lung. Remodelling of the metastatic microenvironment is essential for tumour metastasis. Neutrophil-associated metastatic microenvironment contributes to the early metastatic colonisation of cancer cells in the lung.

Method

The lung metastasis models were constructed via treated cancer cells by tail vein injection into mice. And samples of lung were harvested at the indicated time to analyze tumor growth and immune cells in the microenvironment. Tumors and lung metastasis specimens were obtained via surgical operations for research purposes. Neutrophils were obtained from peripheral blood of patients with liver cancer or healthy donors (H

SUBMITTER: Yin Y 

PROVIDER: S-EPMC10230156 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature