Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin.

ABSTRACT:

Background

Radiation-induced skin injury, which may progress to fibrosis, is a severe side effect of radiotherapy in patients with cancer. However, currently, there is a lack of preventive or curative treatments for this injury. Meanwhile, the mechanisms underlying this injury remain poorly understood. Here, we elucidated whether autophagy is essential for the development of radiation-induced skin injury and the potential molecular pathways and mechanisms involved.

Methods and results

We used the myofibroblast-specific Atg7 knockout (namely, conditional Atg7 knockout) mice irradiated with a single electron beam irradiation dose of 30 Gy. Vaseline-based 0.2% rapamycin ointment was topically applied once daily from the day of irradiation for 30 days. On day 30 post irradiation

SUBMITTER: Chen X 

PROVIDER: S-EPMC10230157 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature