Underweight children older than 5 years with sickle cell anemia are at risk for early mortality in a low-resource setting.

ABSTRACT: Undernutrition is a risk factor for under-5 mortality and is also postulated to be a risk factor for mortality in older children and adults with sickle cell anemia (SCA). We tested the hypothesis that underweight is associated with mortality in children aged 5 to 12 years with SCA. We performed a secondary analysis of participants in the Primary Prevention of Stroke in Children with Sickle Cell Disease in Nigeria trial, a double-blind, parallel-group randomized controlled trial for low-dose or moderate-dose hydroxyurea in children with abnormal transcranial Doppler velocities and a comparison group of participants with nonelevated transcranial Doppler velocities in northern Nigeria. Nutritional status was classified as underweight (weight-for-age z score), stunting (height-for-age z score)

SUBMITTER: Klein LJ 

PROVIDER: S-EPMC10230165 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature