Administration of the glutamate-modulating drug, riluzole, after stress prevents its delayed effects on the amygdala in male rats.

ABSTRACT: Extracellular glutamate levels are elevated across brain regions immediately after stress. Despite sharing common features in their genesis, the patterns of stress-induced plasticity that eventually take shape are strikingly different between these brain areas. While stress causes structural and functional deficits in the hippocampus, it has the opposite effect on the amygdala. Riluzole, an FDA-approved drug known to modulate glutamate release and facilitate glutamate clearance, prevents stress-induced deficits in the hippocampus. But whether the same drug is also effective in countering the opposite effects of stress in the amygdala remains unexplored. We addressed this question by using a rat model wherein even a single 2-h acute immobilization stress causes a delayed expression of anxie

SUBMITTER: Datta S 

PROVIDER: S-EPMC10230288 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature