Longitudinal Associations of Clinical and Biochemical Head Injury Biomarkers With Head Impact Exposure in Adolescent Football Players.

ABSTRACT:

Importance

Consequences of subconcussive head impacts have been recognized, yet most studies to date have included small samples from a single site, used a unimodal approach, and lacked repeated testing.

Objective

To examine time-course changes in clinical (near point of convergence [NPC]) and brain-injury blood biomarkers (glial fibrillary acidic protein [GFAP], ubiquitin C-terminal hydrolase-L1 [UCH-L1], and neurofilament light [NF-L]) in adolescent football players and to test whether changes in the outcomes were associated with playing position, impact kinematics, and/or brain tissue strain.

Design, setting, and participants

This multisite, prospective cohort study included male high school football players aged 13 to 18 years at 4 high schools in the Midwest duri

SUBMITTER: Zuidema TR 

PROVIDER: S-EPMC10230318 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature