Genomic characteristics of Mycobacterium tuberculosis isolates of cutaneous tuberculosis.

ABSTRACT:

Objectives

Cutaneous tuberculosis with various manifestations can be divided into several clinical types according to the host's immune status and infective route. However, the etiological factors of this disease remain unclear. The objective of this study is to investigate the pathogens associated with the occurrence and different types of cutaneous tuberculosis.

Methods

58 Mycobacterium tuberculosis strains isolated from cutaneous tuberculosis over the last 20 years were sequenced and analyzed for genomic characteristics including lineage distribution, drug-resistance mutations, and mutations potentially associated with different sites of infection.

Results

The M. tuberculosis strains from four major types of cutaneous tuberculosis and pulmonary tuberc

SUBMITTER: Mei YM 

PROVIDER: S-EPMC10230547 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature