A Temporin Derived Peptide Showing Antibacterial and Antibiofilm Activities against Staphylococcus aureus.

ABSTRACT:

Background

Temporin is one family of the shortest antimicrobial peptides found in Ranidae frogs. Staphylococcus aureus is one of the main pathogens of suppurative diseases and food contamination, causing severe local or systemic infections in humans. Temporin-GHa (GHa) was previously obtained from Hylarana guentheri, showing weak antibacterial activity against S. aureus. Most temporin peptides are positively charged by arginine and lysine; however, GHa contains histidine.

Objective

In order to investigate the impact of positively charged amino acid on its antibacterial and antibiofilm activity, GHa4R was designed and synthesized by replacing histidine with arginine in GHa.

Methods

The antibacterial activity and efficacy against S. aureus were detected by minimum inhib

SUBMITTER: An M 

PROVIDER: S-EPMC10230607 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature