ILC2 regulates hyperoxia-induced lung injury via an enhanced Th17 cell response in the BPD mouse model.

ABSTRACT:

Backgroud

Recent research has focused on the role of immune cells and immune responses in the pathogenesis of bronchopulmonary dysplasia (BPD), but the exact mechanisms have not yet been elucidated. Previously, the key roles of type 2 innate lymphoid cells (ILC2) in the lung immune network of BPD were explored. Here, we investigated the role Th17 cell response in hyperoxia-induced lung injury of BPD, as well as the relationship between ILC2 and Th17 cell response.

Methods

A hyperoxia-induced BPD mouse model was constructed and the pathologic changes of lung tissues were evaluated by Hematoxylin-Eosin staining. Flow cytometry analysis was conducted to determine the levels of Th17 cell, ILC2 and IL-6⁺ILC2. The expression levels of IL-6, IL-17 A, IL-17 F, and IL-22 i

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10230686 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature