Epstein-Barr virus variation in people living with human immunodeficiency virus in southeastern China.

ABSTRACT:

Background

Patients infected with HIV are at high risk of developing Epstein-Barr Virus (EBV)-related diseases. The genotype and viral biological behavior of EBV infection in patients with human immunodeficiency virus-1 (HIV) in China remain unclear. This study analyzed the characteristics of EBV in patients infected with HIV in southeastern China.

Methods

A total of 162 HIV-infected patients and 52 patients without HIV were enrolled in this study. EBV viral load in blood was determined by fluorescence quantitative PCR. EBV typing was performed using saliva according to polymorphisms in the EBNA3C region. EBV LMP-1 carboxy terminus (C-ter) was sequenced, and compared with the epidemic strains in the world.

Results

Among HIV infected patients, the EBV strain variant wa

SUBMITTER: Wan Z 

PROVIDER: S-EPMC10230783 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature