Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart.

ABSTRACT:

Background

Glucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3',5'-cyclic adenosine monophosphate (cAMP) production in the myocardium. This has been confirmed in animal studies but not in the human heart. The cardiostimulatory effects of glucagon have been correlated with the degree of cardiac dysfunction, as well as with the enzymatic activity of phosphodiesterase (PDE), which hydrolyses cAMP. In this study, the presence of glucagon receptors in the human heart and the inotropic and chronotropic effects of glucagon in samples of failing and nonfailing (NF) human hearts were investigated.

Methods

Concentration‒response curves for glucagon in the absence and presence of the PDE inhibitor IBMX were performed on sample

SUBMITTER: Aranda-Domene R 

PROVIDER: S-EPMC10230788 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature