Alterations in inflammatory markers after a 12-week exercise program in individuals with schizophrenia-a randomized controlled trial.

ABSTRACT:

Background

In individuals with schizophrenia, inflammation is associated with depression, somatic comorbidity and reduced quality of life. Physical exercise is known to reduce inflammation in other populations, but we have only limited knowledge in the field of schizophrenia. We assessed inflammatory markers in plasma samples from individuals with schizophrenia participating in an exercise intervention randomized controlled trial. We hypothesized that (i) physical exercise would reduce levels of inflammatory markers and (ii) elevated inflammatory status at baseline would be associated with improvement in cardiorespiratory fitness (CRF) following intervention.

Method

Eighty-two individuals with schizophrenia were randomized to a 12-week intervention of either high-intensity i

SUBMITTER: Bigseth TT 

PROVIDER: S-EPMC10231033 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature