Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8⁺ T cells.

ABSTRACT: The networks of transcription factors (TFs) that control intestinal-resident memory CD8⁺ T (T_RM) cells, including multipotency and effector programs, are poorly understood. In this work, we investigated the role of the TF Bcl11b in T_RM cells during infection with Listeria monocytogenes using mice with post-activation, conditional deletion of Bcl11b in CD8⁺ T cells. Conditional deletion of Bcl11b resulted in increased numbers of intestinal T_RM cells and their precursors as well as decreased splenic effector and circulating memory cells and precursors. Loss of circulating memory cells was in part due to increased intestinal homing of Bcl11b^-/- circulating precursors, with no major alterations in their programs. <

SUBMITTER: Helm EY 

PROVIDER: S-EPMC10231135 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature