Expanding the Physiological Role of Aryl-Alcohol Flavooxidases as Quinone Reductases.

ABSTRACT: Aryl-alcohol oxidases (AAOs) are members of the glucose-methanol-choline oxidase/dehydrogenase (GMC) superfamily. These extracellular flavoproteins have been described as auxiliary enzymes in the degradation of lignin by several white-rot basidiomycetes. In this context, they oxidize fungal secondary metabolites and lignin-derived compounds using O₂ as an electron acceptor, and supply H₂O₂ to ligninolytic peroxidases. Their substrate specificity, including mechanistic aspects of the oxidation reaction, has been characterized in Pleurotus eryngii AAO, taken as a model enzyme of this GMC superfamily. AAOs show broad reducing-substrate specificity in agreement with their role in lignin degradation, being able to oxidize both nonphenolic and phenolic aryl alcoh

SUBMITTER: Ferreira P 

PROVIDER: S-EPMC10231232 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature