Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research.

ABSTRACT: Bronchoalveolar lavage (BAL) is becoming a common procedure for research into infectious disease immunology. Little is known about the clinical factors which influence the main outcomes of the procedure. In research participants who underwent BAL according to guidelines, the BAL volume yield, and cell yield, concentration, viability, pellet colour and differential count were analysed for association with important participant characteristics such as active tuberculosis (TB) disease, TB exposure, HIV infection and recent SARS-CoV-2 infection. In 337 participants, BAL volume and BAL cell count were correlated in those with active TB disease, and current smokers. The right middle lobe yielded the highest volume. BAL cell and volume yields were lower in older participants, who also had more ne

SUBMITTER: Shaw JA 

PROVIDER: S-EPMC10231287 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature