Low adherence to recommended use of neoadjuvant chemotherapy for muscle-invasive bladder cancer.

ABSTRACT:

Purpose

To evaluate guideline adherence and variation in the recommended use of neoadjuvant chemotherapy (NAC) and the effects of this variation on survival in patients with non-metastatic muscle-invasive bladder cancer (MIBC).

Patients and methods

In this nationwide, Netherlands Cancer Registry-based study, we identified 1025 patients newly diagnosed with non-metastatic MIBC between November 2017 and November 2019 who underwent radical cystectomy. Patients with ECOG performance status 0-1 and creatinine clearance ≥ 50 mL/min/1.73 m² were considered NAC-eligible. Interhospital variation was assessed using case-mix adjusted multilevel analysis. A Cox proportional hazards model was used to evaluate the association between hospital specific probability of using NAC a

SUBMITTER: van Hoogstraten LMC 

PROVIDER: S-EPMC10231297 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature