Cytolytic CD8⁺ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes.

ABSTRACT: Follicular CD8⁺ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers against lymphotropic infections and cancers, but the precise mechanisms by which these cells mediate immune control remain incompletely resolved. To address this, we investigated functionality, clonotypic compartmentalization, spatial localization, phenotypic characteristics, and transcriptional profiles of LN-resident virus-specific CD8⁺ T cells in persons who control HIV without medications. Antigen-induced proliferative and cytolytic potential consistently distinguished spontaneous controllers from noncontrollers. T cell receptor analysis revealed complete clonotypic overlap between peripheral and LN-resident HIV-specific CD8⁺ T cells. Transcriptional analysis of LN C

SUBMITTER: Collins DR 

PROVIDER: S-EPMC10231436 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature