Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin⁺ foam cell differentiation in the prostate.

ABSTRACT: Benign prostatic hyperplasia (BPH) occurs progressively with aging in men and drives deteriorating symptoms collectively known as lower urinary tract symptoms (LUTS). Age-associated changes in circulating steroid hormones, and prostate inflammation have been postulated in the etiology of BPH/LUTS. The link between hormones and inflammation in the development of BPH/LUTS is conflicting because they may occur independently or as sequential steps in disease pathogenesis. This study aimed to decipher the prostatic immune landscape in a mouse model of lower urinary tract dysfunction (LUTD). Steroid hormone imbalance was generated by the surgical implantation of testosterone (T) and estradiol (E2) pellets into male C57BL/6J mice and gene expression analysis was performed on ventral prostates (VP

SUBMITTER: Popovics P 

PROVIDER: S-EPMC10231633 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature