Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke.

ABSTRACT:

Introduction

Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological and biological factors. Lesion location is a readily available information in stroke patients, but it is unclear if the neurobiological substrates of PSDS are spatially localized. Building on previous analyses, we sought to determine if PSDS are associated with specific lesion locations, structural disconnection and/or localized functional diaschisis.

Methods

In a prospective observational study, we examined 270 patients with first-ever stroke with the Hospital Anxiety and Depression Scale (HADS) around 6 months post-stroke. Based on individual lesion locations and the depression subscal

SUBMITTER: Klingbeil J 

PROVIDER: S-EPMC10231644 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature