Effects of herpes zoster vaccination and antiviral treatment on the risk of stroke: a systematic review and meta-analysis.

ABSTRACT:

Background

Evidence suggests that there is an increased risk of stroke after herpes zoster (HZ). However, reports on the effects of HZ vaccination (HZV) and antiviral treatment on stroke risk are inconsistent. Thus, we examined these associations in a meta-analysis.

Methods

To identify relevant studies, we searched three databases for articles published up to January 2023. Random-effect models were examined to determine overall pooled estimates and 95% confidence intervals (CIs).

Results

This review included 12 observational studies (six on HZV and seven on antiviral treatment). When comparing vaccinated and unvaccinated patients, vaccination was found to be associated with a lower risk of stroke (OR, 0.78; 95% CI 0.68-0.9; P = 0.001). A meta-analysis of self-c

SUBMITTER: Jia YH 

PROVIDER: S-EPMC10231675 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature